Citation: Wen Gu, Hui Ding. Two new tetralone derivatives from the culture of Xylaria hypoxylon AT-028[J]. Chinese Chemical Letters, ;2008, 19(11): 1323-1326. doi: 10.1016/j.cclet.2008.09.006 shu

Two new tetralone derivatives from the culture of Xylaria hypoxylon AT-028

Wen Gu ,
Hui Ding

Department of Forestry Chemical Engineering, School of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China

Received Date: 8 May 2008

Two new tetralone derivatives named xylariol A (1) and B (2) were isolated from the EtOAc extract of the culture broth of Xylaria hypoxylon AT-028 (Xylariaceae),and their structures were elucidated by MS,IR,ID-and 2D-NMR spectra,and by X-ray diffraction analysis. 1 and 2 showed moderate cytotoxic activities against Hep G2 cells in the in vitro cytotoxic assay with ICso values of 22.3 and 21.2 μg/mL,respectively.
- Xylaria hypoxylon,
- Xylariol A,
- Xylariol B,
- Cytotoxicity
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