Citation:
Tao Wang, Yi Hua Zhang, Shan Yu, Hui Ji, Yi Sheng Lai, Si Xun Peng. Synthesis and biological evaluation of novel thalidomide analogues as potential anticancer drugs[J]. Chinese Chemical Letters,
;2008, 19(8): 928-930.
doi:
10.1016/j.cclet.2008.05.044
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In search of novel anticancer agents, a series of thalidomide analogs (6a-j) were designed and synthesized.Cytotoxicity of these compounds against human hepatoma cells (HepG2) was evaluated by MTT method.Compounds 6d, 6h and 6i showed significant cytotoxic activities comparable to or stronger than control 5-fluorouracil.
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Keywords:
- Thalidomide,
- 1,3,4-Thiadiazole,
- Anti-tumor activity,
- HepG2
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