Citation: Yan Ming Liu, Jun Tao Cao, Hui Wang. Capillary electrophoresis with electrochemiluminescence detection for the analysis of quinolone drugs and pharmacokinetics study[J]. Chinese Chemical Letters, ;2008, 19(8): 962-964. doi: 10.1016/j.cclet.2008.05.027 shu

Capillary electrophoresis with electrochemiluminescence detection for the analysis of quinolone drugs and pharmacokinetics study

College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 464000, China

Received Date: 28 January 2008

Fund Project: This work was supported by the National Natural Science Foundation of China (No.20575056) and Henan Innovation Project for University Research Talents (No.2005126)

A novel method for the determination of two quinolone drugs norfloxacin (NOR) and levofloxacin (LVX) was described by capillary electrophoresis with electrochemiluminescence detection.The good relationship (r≥0.9991) between peak area and concentration of analytes was established over two orders of magnitude.The limits of detection (LOD, S/N=3) in standard solution are 4.8×10^-7 mol/L for NOR and 6.4×10^-7mol/L for LVX, respectively.The limits of quantitation (LOQ, S/N=10) in real human urine samples are 1.2×10^-6 mol/L for NOR and 1.4×10^-6 mol/L for LVX, respectively.The present method was successfully applied to the determination of NOR and LVX in human urine and the study of pharmacokinetics of NOR.
- Capillary electrophoresis,
- Electrochemiluminescence detection,
- Quinolone drugs,
- Urine analysis,
- Pharmacokinetics
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