Citation: Ali R. Kiasat, Maryam Zayadi, Mehdi Fallah Mehrjardi. Regioselective ring opening of epoxides using NH₄SCN/silica sulfuric acid:An efficient approach for the synthesis of β-hydroxy thiocyanate under solvent-free conditions[J]. Chinese Chemical Letters, ;2008, 19(6): 665-668. doi: 10.1016/j.cclet.2008.04.004 shu

Regioselective ring opening of epoxides using NH₄SCN/silica sulfuric acid:An efficient approach for the synthesis of β-hydroxy thiocyanate under solvent-free conditions

Chemistry Department, College of Science, Shahid Chamran University, Ahvaz 61357-4-3169, Iran

Received Date: 2 January 2008

Silica sulfuric acid was developed as a stable and efficient heterogeneous catalyst in organic synthesis. This solid acid catalyzed the regioselective ring opening of epoxides by thiocyanate anion to give thiocyanohydrins as key intermediates in agricultural and pharmaceutical chemistry in high yields under solvent-free conditions.
- Silica sulfuric acid,
- Thiocyanohydrins,
- β-Hydroxy thiocyanate,
- Epoxide,
- Solvent-free
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