Citation: Yi Luo, Ping Zhong, Xiao Hong Zhang, Qiu Lian Lin, Ye Na Chen. Formylation of N-arylpyrazole containing active amino group using Vilsmeier-Hacck reaction[J]. Chinese Chemical Letters, ;2008, 19(4): 383-386. doi: 10.1016/j.cclet.2008.01.025 shu

Formylation of N-arylpyrazole containing active amino group using Vilsmeier-Hacck reaction

College of Chemistry and Materials Science, Wenzhou University, Wenzhou 325027, China

Received Date: 24 October 2007

Fund Project: Project supported by the National Natural Science Foundation of China (No. 20572079), the Natural Science Foundation of Zhejiang Province (No. Y407079) and the Foundation of Science and Technology Department of Zhejiang Province (No. 2007C21116).

Two species of N-arylpyrazoles containing active amino group were synthesized.And formylations of N-arylpyazoles containing amino in different position of pyrazole rings using Vilsmeier-Hacck reaction gave a series of useful pyrazole intermediates.The important features of this protocol were cheap materials, easy process, mild reaction conditions and good yield of products.
- Vilsmeier-Haack reaction,
- N-arylpyrazole,
- Formylation,
- Amino,
- Synthesis
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