Citation: Yu Li, Hui Bin Zhang, Wen Long Huang, Xia Zhen, Yun Man Li. Synthesis and biological evaluation of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer[J]. Chinese Chemical Letters, ;2008, 19(2): 169-171. doi: 10.1016/j.cclet.2007.12.016 shu

Synthesis and biological evaluation of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer

Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China

Received Date: 22 October 2007

Fund Project: The work was supported by the Hi-tech Research and Development Program of China (No. 2002AA233071).

Tetrahydroisoquinoline derivatives were synthesized and their multidrug resistance reversal activities were evaluated in vitro.The results showed that some of the synthetic compounds had higher multidrug resistance (MDR) reversal activities than verapamil.
- Tetrahydroisoquinoline derivatives,
- Synthesis,
- Multidrug resistance (MDR),
- Peptoids
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