Citation: Fan Cheng, Xiang Li, Jun Zhi Wang. A new alkaloid from Solanum cathayanum[J]. Chinese Chemical Letters, ;2008, 19(1): 68-70. doi: 10.1016/j.cclet.2007.10.041 shu

A new alkaloid from Solanum cathayanum

a Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China;
b Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

Received Date: 13 July 2007

Fund Project: This work was financially supported by Open Foundation of Hubei Key Laboratory of Natural Products Research and Development(No.2006NP05).The plant material was identified by associate Prof.Jing Yang, China Three Gorges University, Yichang, Hubei.

A new alkaloid compound 1 was obtained from Solanum cathayanum, a folk medicine of Hubei Province, together with a known alkaloid, orotic acid ethyl ester. On the basis of spectroscopic data and chemical methods, was identified as 8-hydroxy-3-methoxy-5H-pyrido[2,1-c]pyrazin-5-one. Compound can inhibit the production of NO in peritoneal macrophage of mice induced with LPS. The content of NO was determined by enzyme methods.
- Alkaloid,
- Solanum cathayanum,
- Folk medicine,
- Nitrogen monoxide
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