Citation: Ye Qing Li, Ming Lu, Chun Xu Lu, Sai Jian Zhu, Qi Fa Liu. Facile synthesis of 9-(N-amino-4-fluoromethyl-3-pyrrolidinyl)-2-fluoro-6-aminopurine from trans-4-hydroxy-L-proline[J]. Chinese Chemical Letters, ;2007, 18(11): 1313-1315. doi: 10.1016/j.cclet.2007.09.020 shu

Facile synthesis of 9-(N-amino-4-fluoromethyl-3-pyrrolidinyl)-2-fluoro-6-aminopurine from trans-4-hydroxy-L-proline

Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094, PR China

Received Date: 29 April 2007

A novel and simple procedure for synthesis of azanucleoside by Mitsunobu reaction between N-(p-nitrobenzyloxycarbonyl)-trans-4-hydroxy-D-proline methyl ester obtained from trans-4-hydroxy-L-proline after six-step reaction and 2-fluoro-6-azidopurine is described, and azanucleoside is fluorinated by new fluridizer 2, 2-difluoro-1, 3-dimethylimidazolidine (DFI). All reactions could be carried out under mild condition.
- trans-4-Hydroxy-o-proline,
- 2-Fluoro-6-azidopurine,
- Fluoride azanucleosides,
- Mitsunobu reaction,
- DFI
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