Citation: Dong Hong Li, Jun Lin Diao, Ke Gui Yu, Cheng He Zhou. Synthesis and anticancer activities of porphyrin induced anticancer drugs[J]. Chinese Chemical Letters, ;2007, 18(11): 1331-1334. doi: 10.1016/j.cclet.2007.09.012 shu

Synthesis and anticancer activities of porphyrin induced anticancer drugs

a State Key Laboratory of Trauma, Burn and Combined Injury, the;
2.
nd Department of Research Institute of Surgery, the third Military Medical University, Chongqing 400042, China;
b School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

Received Date: 7 June 2007

Fund Project: The authors would like to express thanks to the Chongqing Science and Technology Council,for the financial support to this work.

In view of the property of porphyrin's accumulation selectively in tumor, the ftorafur was modified by binding a porphyrin block to improve its tumor targeting and reduce its side effects. These novel porphyrin derivatives and metal compounds were synthesized under mild conditions with satisfactory yield, and the constructions of all these new compounds were characterized by UV, IR, MS, ¹H NMR spectra and elementary analysis. Their anticancer activities were evaluated by MTT assay; the results indicated that the anticancer activities of compounds 4a-c were twice as high as that of ftorafur.
- Porphyrin,
- Ftorafur,
- Synthesis,
- Anticancer activities
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