Citation: Hong Gang Hu, Ming Juan Wang, Qing Jie Zhao, Shi Chong Yu, Chao Mei Liu, Qiu Ye Wu. Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity[J]. Chinese Chemical Letters, ;2007, 18(11): 1323-1326. doi: 10.1016/j.cclet.2007.09.011 shu

Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity

a Department of Chemistry, College of Science, Wayne State University, Detroit, MI 48202, United States;
b Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 5 June 2007

Fund Project: We thank The National Center for Drug Screening (Shanghai,PR China) for supplying data on PTP1B inhibitory activity of the compounds.This work was supported by a grant from Science&Technology Commission of Shanghai Municipality (No.054319909).

Protein tyrosine phosphatase 1B (PTP1B) has received considerable attention from the drug industry as a potential treatment fordiabetes mellitus. Mangiferin has been reported to possess significant antidiabetic activity. Based on the previous study, eight new mangiferin derivates were synthesized and evaluated for their PTP1B inhibitory activity. Some of them displayed good inhibitory activity on PTP1B.
- Mangiferin,
- Protein tyrosine phosphatase 1B,
- Derivates,
- Inhibition
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