Citation: Nagnnath D. Kokare, Jaiprkash N. Sangshetti, Devanand B. Shinde. Oxalic acid catalyzed solvent-free one pot synthesis of coumarins[J]. Chinese Chemical Letters, ;2007, 18(11): 1309-1312. doi: 10.1016/j.cclet.2007.09.008 shu

Oxalic acid catalyzed solvent-free one pot synthesis of coumarins

a Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004(MS), India;
b Wockhardt Research Centre, New Drug Discovery, Aurangabad 431210(MS), India

Received Date: 22 May 2007

Fund Project: The authors are thankful to the Head,Department of Chemical Technology,Dr.Babasaheb Ambedkar Marathwada University,Aurangabad 431004(MS),India for providing the laboratory facility.

Oxalic acid was found to be an efficient catalyst for Pechmann condensation, which includes the reaction between phenols and β-keto esters leading to formation of coumarin derivatives. The advantages of present methods are the use of cheap and easy available catalyst, solvent-free reaction conditions, better yields and shorter reaction time.
- Coumarins,
- Oxalic acid,
- Solvent-free reaction,
- Pechmann condensation,
- β-Keto esters,
- Phenols
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