Citation: Rong Zhang Qiao, Bai Ling Xu, Yan Hui Wang. A facile synthesis of 2-substituted-2, 3-dihydro-4(1H)-quinazolinones in 2, 2, 2-trifluoroethanol[J]. Chinese Chemical Letters, ;2007, 18(6): 656-658. doi: 10.1016/j.cclet.2007.04.036 shu

A facile synthesis of 2-substituted-2, 3-dihydro-4(1H)-quinazolinones in 2, 2, 2-trifluoroethanol

a Department of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China;
b Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Fund Project: We thank the National Natural Science Foundation of China (No. 30672540) and NSF of Beijing (No. 7072048) for financial support.

2-Substituted-2, 3-dihydro-4(1H)-quinazolinones Were obtained in high yields by condensation of anthranilamide with aryl, alkyl or heteroaryl aldehydes or ketones in the refluxing 2, 2, 2-trifluoroethanol without any catalyst.
- 2, 3-Dihydro-4(1H)-quinazolinone,
- Trifluoroethanol (TFE),
- Fluorinated solvent
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