Citation: Yong Gao, Jian Li Li, Zhen Shi. Synthesis and application of rhodamine-based fluorescent probe dyes with spacer linker arm[J]. Chinese Chemical Letters, ;2007, 18(6): 667-669. doi: 10.1016/j.cclet.2007.04.007 shu

Synthesis and application of rhodamine-based fluorescent probe dyes with spacer linker arm

Yong Gao ^a,b, ,
Jian Li Li ^b ,
Zhen Shi ^b

a College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China;
b Department of Chemistry, Northwest University, Xi'an 710069, China

Received Date: 1 December 2006

Fund Project: We are very grateful to the National Natural Science Foundation of China (No. 20472067), the Ph.D. Program Foundation of Chinese University (No. 20050697003) and the Science Foundation of Education Department of Fujian Province (No. JB06070) for the financial support.

When rhodamine-based fluorescent probe dyes are used to track target molecules they always perturb the behavior of target molecules because of steric hindrance effect.In order to minimize potential steric problems, a kind of rhodamine-based fluorescent probe dye with spacer linker arm was designed and synthesized and its application in immunofluorescence histochemistry was investigated.
- Rhodamine,
- Fluorescent probe dye,
- Spacer linker arm,
- Synthesis,
- Immunofluorescence histochemistry
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