Citation: Zhen Gang Liu, Nan Li, Li Yang, Zhong Li Liu, Wei Yu. ZrCl₄/Hantzsch 1,4-dihydropyridine as a new and efficient reagent combination for the direct reductive amination of aldehydes and ketones with weakly basic amines[J]. Chinese Chemical Letters, ;2007, 18(4): 458-460. doi: 10.1016/j.cclet.2007.02.013 shu

ZrCl₄/Hantzsch 1,4-dihydropyridine as a new and efficient reagent combination for the direct reductive amination of aldehydes and ketones with weakly basic amines

State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China

Received Date: 13 September 2006

Fund Project: We thank the National Natural Science Foundation of China (No. 20372030) for financial support.

ZrCl₄/Hantzsch 1,4-dihydropyridine is a mild and highly efficient reagent combination for the direct reductive amination.Weakly basic amines such as anilines substituted by electron-withdrawing group and heteroaromatic amines can be reductivelyalkylated with electron rich aldehydes and ketones under mild conditions to form the secondary amines in excellent yields.
- Zirconium tetrachloride,
- Hantzsch 1,4-dihydropyridine,
- Reductive amination
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