Citation: Hong Chen, Ying Wang, Ling Leng, Mao Sheng Cheng, Peng Fei Yu, Jing Ze Zhang. A new series of emodin derivatives with bone affinity[J]. Chinese Chemical Letters, ;2007, 18(2): 141-144. doi: 10.1016/j.cclet.2006.12.021 shu

A new series of emodin derivatives with bone affinity

a Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China;
b Shenyang Pharmaceutical University, Shenyang 110016, China

Received Date: 1 September 2006

Fund Project: This work was supported by the National Natural Science Foundation of China (no. 30371682).

A new series of bone affinity compounds were synthesized by linking emodin with 5-fluorouracil derivatives. Their bone affinities were established by hydroxyapative (HA) affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.
- Emodin,
- 5-Fluorouracil,
- Bone affinity,
- Antitumor
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