Citation: Ying Li, Yi Cao. The Physical Chemistry for the Self-assembly of Peptide Hydrogels[J]. Chinese Journal of Polymer Science, ;2018, 36(3): 366-378. doi: 10.1007/s10118-018-2099-6 shu

The Physical Chemistry for the Self-assembly of Peptide Hydrogels

Ying Li ^a ,
Yi Cao ^b,,

a.
Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, School of Environmental Science and Engineering, Jiangsu Engineering Technology Research Centre of Environmental Cleaning Materials, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Jiangsu Joint Laboratory of Atmospheric Pollution Control, Nanjing University of Information Science & Technology, Nanjing 210044, China
b.
Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210093, China

Corresponding author: Yi Cao, caoyi@nju.edu.cn
Received Date: 3 November 2017
Accepted Date: 3 December 2017
Available Online: 28 December 2017

Peptide hydrogels have been widely used for diverse biomedical applications. However, our current understanding of the physical principles underlying the self-assembly process is still limited. In this review, we summarize our current understanding on the physical chemistry principles from the basic interactions that drive the self-assembly process to the energy landscapes that dictate the thermodynamics and kinetics of the process. We discuss the effect of different factors that affect the kinetics of the self-assembly of peptide fibrils and how this is related to the macroscopic gelation process. We provide our understanding on the molecular origin of the complex and rugged energy landscape for the self-assembly of peptide hydrogels. The hierarchical self-assembled structures and the diverse self-assembling mechanism make it difficult and challenging to rationally design the physical and chemical properties of peptide hydrogels at the molecular level. We also give our personal perspective to the potential future directions in this field.
- Hydrogel,
- Peptide,
- Self-assembly,
- Kinetics,
- Thermodynamics
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