Citation: Hao Wang, Ting-Ting Dai, Bo-Lun Lu, Sheng-Li Li, Qing Lu, Vincent Mukwaya, Hong-Jing Dou. Hybrid Dextran-gadolinium Nano-suitcases as High-relaxivity MRI Contrast Agents[J]. Chinese Journal of Polymer Science, ;2018, 36(3): 391-398. doi: 10.1007/s10118-018-2083-1 shu

Hybrid Dextran-gadolinium Nano-suitcases as High-relaxivity MRI Contrast Agents

Hao Wang ^a,† ,
Ting-Ting Dai ^b,† ,
Bo-Lun Lu ^b ,
Sheng-Li Li ^b ,
Qing Lu ^c ,
Vincent Mukwaya ^a ,
Hong-Jing Dou ^a,,

a.
The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
b.
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai 200011, China
c.
Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Corresponding author: Hong-Jing Dou, hjdou@sjtu.edu.cn

^†

Received Date: 30 September 2017
Accepted Date: 2 November 2017
Available Online: 18 December 2017

Dextran-poly(glycidyl methacrylate) (Dex-PGMA) nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly (GISA) approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd(ó) ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd(ó) ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd(ó) ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity (r₁) of the hybrid nano-suitcases is reported as 44.4 L/(mmol·s), which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.
- Crosslinked polymer nanoparticles,
- Gadolinium(Ⅲ),
- MRI contrast agents,
- Lymph node imaging
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