Citation: Xiao-ming Sun, Jin-xia Xu, Jian-bin Tang, Mei-hua Sui, and, You-qing Shen. FOLATE-TARGETED OPTICAL AND MAGNETIC RESONANCE DUAL-MODALITY PCL-b-PEG MICELLES FOR TUMOR IMAGING[J]. Chinese Journal of Polymer Science, ;2011, 29(4): 427-430. doi: 10.1007/s10118-011-1057-3 shu

FOLATE-TARGETED OPTICAL AND MAGNETIC RESONANCE DUAL-MODALITY PCL-b-PEG MICELLES FOR TUMOR IMAGING

Received Date: 25 March 2011
Revised Date: 21 April 2011

Fund Project: National Natural Science Foundation of Chinathe Doctoral Fund of Ministry of Education of Chinathe National Basic Research Program (973 Program) of Chinathe Qianjiang Talent Program of Zhejiang Province, China

A biodegradable tumor targeting nano-probe based on poly(e-caprolactone)-b-poly(ethylene glycol) block copolymer (PCL-b-PEG) micelle functionalized with a magnetic resonance imaging (MRI) contrast agent diethylenetriaminepentaacetic acid-gadolinium (DTPA-Gd3+)on the shell and a near-infrared (NIR) dye in the core for magnetic resonance and optical dual-modality imaging was prepared. The longitudinal relaxivity (r1) of the PCL-b-PEG-DTPA-Gd3+micelle was 13.4 (mmol/L)-1s-1, three folds of that of DTPA-Gd3+, and higher than that of many polymeric contrast agents with similar structures. The in vivo optical imaging of a nude mouse bearing xenografted breast tumor showed that the dual-modality micelle preferentially accumulated in the tumor via the folic acid-mediated active targeting and the passive accumulation by the enhanced permeability and retention (EPR) effect. The results indicated that the dual-modality micelle is a promising nano-probe for cancer detection and diagnosis.
- Dual-modality
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