Glutathione as the End Capper for Cyclodextrin/PEG Polyrotaxanes

Qiao Song Zhi Luo Xinming Tong Yi Du Yanbin Huang

Citation:  Qiao Song, Zhi Luo, Xinming Tong, Yi Du, Yanbin Huang. Glutathione as the End Capper for Cyclodextrin/PEG Polyrotaxanes[J]. Chinese Journal of Polymer Science, 2014, 32(8): 1003-1009. doi: 10.1007/s10118-014-1477-y shu

Glutathione as the End Capper for Cyclodextrin/PEG Polyrotaxanes

  • 基金项目:

    This work was financially supported by the National Natural Science Foundation of China (No. 21004038)

摘要: A facile one-pot synthesis of a-cyclodextrin-based polyrotaxane (PR) in aqueous solution is reported, where the peptide glutathione was used as the end-capping agent and the thiol-ene Michael addition was used as the end-capping reaction. Both polyrotaxanes with low threading ratio and high threading ratio were successfully obtained. In contrast to the conventionally used multiple-step synthesis methods and hydrophobic end cappers, this one-pot aqueous synthesis as well as the biocompatibility of the end-capping agent could result in a much more biocompatible PR to be used as biomaterials.

English


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  • 发布日期:  2014-08-05
  • 收稿日期:  2013-11-13
  • 修回日期:  2014-01-11
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