Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers

Citation: Yan Zhang, Shi Liu, Xue Wang, Zhi-yun Zhang, Xia-bin Jing, Ping Zhang, Zhi-gang Xie. Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers[J]. Chinese Journal of Polymer Science, 2014, 32(8): 1111-1118. doi: 10.1007/s10118-014-1491-0 shu

Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers

1.
The First Hospital of Jilin University, Changchun 130021, China
2.
1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
2. The University of Chinese Academy of Sciences, Beijing 100049, China
4.
5.
Health Improving Department, China-Japan Union Hospital of Jilin University, Changchun 130033, China
6.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

摘要: In this study a cisplatin-loaded, multilayered polylactide (PLA) electrospun nanofibers, with the structure of two layers of drug-loaded mat being sandwiched by three layers of blank mat, were designed for prolonged cisplatin release at surgical margin to prevent local cancer recurrence following surgical resection in a murine model. In vivo drug release and biodistribution study suggested that the multilayered fibrous mat displayed a slower cisplatin release behavior and a more stable drug rentention in the local tissue within 24 h than that of single-layered fibrous mat. By covering the surgical site with the multilayered fibrous mat following resection of subcutaneous liver cancer in mice, retarded tumor recurrence, prolonged survival time and less systemic toxicity were observed compared with other treatment groups.

关键词:

English

Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers

1.
The First Hospital of Jilin University, Changchun 130021, China
2.
1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
2. The University of Chinese Academy of Sciences, Beijing 100049, China
4.
5.
Health Improving Department, China-Japan Union Hospital of Jilin University, Changchun 130033, China
6.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
Received Date: 11 December 2013
Revised Date: 03 January 2014
Available Online: 05 August 2014

Abstract: In this study a cisplatin-loaded, multilayered polylactide (PLA) electrospun nanofibers, with the structure of two layers of drug-loaded mat being sandwiched by three layers of blank mat, were designed for prolonged cisplatin release at surgical margin to prevent local cancer recurrence following surgical resection in a murine model. In vivo drug release and biodistribution study suggested that the multilayered fibrous mat displayed a slower cisplatin release behavior and a more stable drug rentention in the local tissue within 24 h than that of single-layered fibrous mat. By covering the surgical site with the multilayered fibrous mat following resection of subcutaneous liver cancer in mice, retarded tumor recurrence, prolonged survival time and less systemic toxicity were observed compared with other treatment groups.

Key words:

1. [1]
  Gelderblom, H., Verweij, J., Nooter, K. and Sparreboom, A., Eur. J. Cancer., 2001, 37(8): 1590
2. [2]
  Langer, R., Chem. Eng. Commun., 1980, 6(1-3): 1
3. [3]
  Davis, M.E., Chen, Z. and Shin, D.M., Nat. Rev. Drug. Discov., 2008, 7(9): 771
4. [4]
  Torchilin, V.P., Adv. Drug. Deliv. Rev., 2006, 58(14): 1532
5. [5]
  Rothenfluh, D.A. and Hubbell, J.A., Integr. Biol. (Camb)., 2009, 1(7): 446
6. [6]
  Weinberg, B.D., Blanco, E. and Gao, J., J. Pharm. Sci., 2008, 97(5): 1681
7. [7]
  Kim, S., Kim, J.H., Jeon, O., Kwon, I.C. and Park, K., Eur. J. Pharm. Biopharm., 2009, 71(3): 420
8. [8]
  Hoffman, A.S., J. Control. Release, 2008, 132(3): 153
9. [9]
  Exner, A.A. and Saidel, G.M., Expert. Opin. Drug Deliv., 2008, 5(7): 775
10. [10]
  Raquel, D. S., Payam, Z. and Christine, A.J., Drug Deliv., 2010, 17(6): 365
11. [11]
  Moses, M.A., Brem, H. and Langer, R., Cancer Cell., 2003, 4(5): 337
12. [12]
  Im, J.S., Kwon, O., Kim,Y.H., Park, S.J. and Lee, Y.S., Micro. Meso. Mater., 2008, 115(21): 514
13. [13]
  Im, J.S., Kim, M.I. and Lee, Y.S., Mater. Lett., 2008, 62(5): 3652
14. [14]
  Im, J.S., Park, S.J., Kim, T.J., Kim, Y.H. and Lee, Y.S., J. Colloid Interface Sci., 2008, 318(9): 42
15. [15]
  Im, J.S., Park, S.J. and Lee,Y.S., J. Colloid Interface Sci., 2007, 314(7): 32
16. [16]
  Suwantong, O. and Ruktanonchai,U.S., Polymer, 2008, 49(19): 4239
17. [17]
  Zamani, M., Prabhakaran, M.P. and Ramakrishna, S., Int. J. Nanomed., 2013, 8: 2997
18. [18]
  Zou, B., Liu, Y., Luo, X., Chen, F., Guo, X. and Li, X., Acta Biomater., 2012, 8(4): 1576
19. [19]
  Yoo, H.S., Kim, T.G. and Park, T.G., Adv. Drug Deliv. Rev., 2009, 61(12): 1033
20. [20]
  Cui, W., Li, X., Zhou, S. and Weng, J., J. Appl. Polym. Sci., 2007, 103(5): 3105
21. [21]
  Li, S.F., Liu, D.X. and Zheng, Y.H., Acta Polymerica Sinica (in Chinese), 2012, (9): 1029
22. [22]
  Liu, R.,Wolinsky, J.B. and Walpole, J., Ann. Surg. Oncol., 2010, 17(4): 1203
23. [23]
  Liu, R., Wolinsky, J.B. and Catalano, P. J., Ann. Surg. Oncol., 2012, 19(1): 199
24. [24]
  Hunter, W.L., Burt, H.M. and Machan, L., Adv. Drug Deliver. Rev., 1997, 26(2-3): 199
25. [25]
  Okuda, T., Tominaga, K. and Kidoaki, S., J. Control. Release, 2010, 143(2): 258

扫一扫看文章

计量

PDF下载量: 0
文章访问数: 991
HTML全文浏览量: 29

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers

English

Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers

English

Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs