引用本文:
Ju Xian Wang, Qiang Guo, Yun Chai, Lian Shun Feng, Hui Yuan Guo, Ming Liang Liu. Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives[J]. Chinese Chemical Letters,
2010, 21(1): 55-58.
doi:
10.1016/j.cclet.2009.07.011
Citation: Ju Xian Wang, Qiang Guo, Yun Chai, Lian Shun Feng, Hui Yuan Guo, Ming Liang Liu. Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives[J]. Chinese Chemical Letters, 2010, 21(1): 55-58. doi: 10.1016/j.cclet.2009.07.011
Citation: Ju Xian Wang, Qiang Guo, Yun Chai, Lian Shun Feng, Hui Yuan Guo, Ming Liang Liu. Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives[J]. Chinese Chemical Letters, 2010, 21(1): 55-58. doi: 10.1016/j.cclet.2009.07.011
Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives
摘要:
A series of novel 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives were designed, synthesized and evaluated for in vitro antibacterial activities. Compounds 8f, 8g, 8i and 8j with the potencies similar to or better than those of levofloxacin and IMB against Staphylococcus aureus and Staphylococcus epidermidis, worth further investigation.
English
Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives
Abstract:
A series of novel 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives were designed, synthesized and evaluated for in vitro antibacterial activities. Compounds 8f, 8g, 8i and 8j with the potencies similar to or better than those of levofloxacin and IMB against Staphylococcus aureus and Staphylococcus epidermidis, worth further investigation.
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Key words:
- Fluoroquinolone
- / Synthesis
- / Antibacterial activities
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