Citation:
LI Ke, LI Shu-Jing, YAO Xin-Jian, NIU Jing-Jing, QIU Xiao-Yang. Syntheses, Crystal Structures and Antimicrobial Activities of Vanadium(V) Complexes with Similar Tridentate Hydrazone Ligands[J]. Chinese Journal of Structural Chemistry,
2015, 34(6): 885-893.
doi:
10.14102/j.cnki.0254-5861.2011-0593
Syntheses, Crystal Structures and Antimicrobial Activities of Vanadium(V) Complexes with Similar Tridentate Hydrazone Ligands
摘要:
Two hydrazone ligands (E)-N'-(2-hydroxy-5-methoxybenzylidene)-2-hydroxybenzohydrazide (HLa) and (E)-N'-(3,5-dichloro-2-hydroxybenzylidene)-4-methoxybenzohydrazide (HLb) were prepared and characterized by IR, UV-Vis and 1H NMR spectra. Based on the hydrazone ligands, two new structurally similar vanadium(V) complexes, [VOLaL]·CH3OH (1) and [VOLbL] (2), where L is the monoanionic form of benzohydroxamic acid (HL), were prepared and characterized by IR and UV-Vis spectra, and single-crystal X-ray diffraction. Complex 1 crystallizes as the monoclinic space group P21/n, with a=7.5208(10), b=15.490(2), c=20.8929(18) Å, β=96.373(2)°, V=2418.9(5) Å3, Z=4, R=0.0831, wR=0.2607 and GOOF=1.061. Complex 2 crystallizes as the monoclinic space group P21/c, with a=11.8577(18), b=16.468(2), c=12.2288(18) Å, β=106.064(2)°, V=2294.7(6) Å3, Z=4, R=0.0741, wR=0.1745 and GOOF=1.014. X-ray analysis indicates that the complexes are mononuclear vanadium (V) species, with the V atoms located in the octahedral coordination. The hydrazone ligands and the complexes were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method.
English
Syntheses, Crystal Structures and Antimicrobial Activities of Vanadium(V) Complexes with Similar Tridentate Hydrazone Ligands
Abstract:
Two hydrazone ligands (E)-N'-(2-hydroxy-5-methoxybenzylidene)-2-hydroxybenzohydrazide (HLa) and (E)-N'-(3,5-dichloro-2-hydroxybenzylidene)-4-methoxybenzohydrazide (HLb) were prepared and characterized by IR, UV-Vis and 1H NMR spectra. Based on the hydrazone ligands, two new structurally similar vanadium(V) complexes, [VOLaL]·CH3OH (1) and [VOLbL] (2), where L is the monoanionic form of benzohydroxamic acid (HL), were prepared and characterized by IR and UV-Vis spectra, and single-crystal X-ray diffraction. Complex 1 crystallizes as the monoclinic space group P21/n, with a=7.5208(10), b=15.490(2), c=20.8929(18) Å, β=96.373(2)°, V=2418.9(5) Å3, Z=4, R=0.0831, wR=0.2607 and GOOF=1.061. Complex 2 crystallizes as the monoclinic space group P21/c, with a=11.8577(18), b=16.468(2), c=12.2288(18) Å, β=106.064(2)°, V=2294.7(6) Å3, Z=4, R=0.0741, wR=0.1745 and GOOF=1.014. X-ray analysis indicates that the complexes are mononuclear vanadium (V) species, with the V atoms located in the octahedral coordination. The hydrazone ligands and the complexes were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method.
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Key words:
- hydrazone
- / vanadium complex
- / mononuclear complex
- / crystal structure
- / antimicrobial activity
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