引用本文:
Yong Mei Xiao, Pu Mao, Zhen Zhao, Liang Ru Yang, Xian Fu Lin. Regioselective enzymatic acylation of troxerutin in nonaqueous medium[J]. Chinese Chemical Letters,
2010, 21(1): 59-62.
doi:
10.1016/j.cclet.2009.08.017
Citation: Yong Mei Xiao, Pu Mao, Zhen Zhao, Liang Ru Yang, Xian Fu Lin. Regioselective enzymatic acylation of troxerutin in nonaqueous medium[J]. Chinese Chemical Letters, 2010, 21(1): 59-62. doi: 10.1016/j.cclet.2009.08.017

Citation: Yong Mei Xiao, Pu Mao, Zhen Zhao, Liang Ru Yang, Xian Fu Lin. Regioselective enzymatic acylation of troxerutin in nonaqueous medium[J]. Chinese Chemical Letters, 2010, 21(1): 59-62. doi: 10.1016/j.cclet.2009.08.017

Regioselective enzymatic acylation of troxerutin in nonaqueous medium
摘要:
A series of monosubstituted troxerutin esters have been synthesized by enzyme-catalyzed regioselective acylation of troxerutin in nonaqueous medium. Using divinyl dicarboxylates (CH2=CH-OOC-(CH2)n-COO-CH=CH2, n=2, 3, 4, 7, 8, 11) featuring different chain length as acyl donors and alkaline protease from Bacillus subtilis as catalyst, troxerutin was regioselective acylated at B' ethoxyl group. The results indicated that the regioselectivity of the enzyme-catalyzed acylation was not affected by the chain length of the acyl donor.
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关键词:
- Troxerutin
- / Acylation
- / Enzymatic synthesis
- / Regioselectivity
English
Regioselective enzymatic acylation of troxerutin in nonaqueous medium
Abstract:
A series of monosubstituted troxerutin esters have been synthesized by enzyme-catalyzed regioselective acylation of troxerutin in nonaqueous medium. Using divinyl dicarboxylates (CH2=CH-OOC-(CH2)n-COO-CH=CH2, n=2, 3, 4, 7, 8, 11) featuring different chain length as acyl donors and alkaline protease from Bacillus subtilis as catalyst, troxerutin was regioselective acylated at B' ethoxyl group. The results indicated that the regioselectivity of the enzyme-catalyzed acylation was not affected by the chain length of the acyl donor.
-
Key words:
- Troxerutin
- / Acylation
- / Enzymatic synthesis
- / Regioselectivity

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