Synthesis of urea acetates as potential PPARα/γ dual agonists

Chang Yan Zhao Chang Qing Shi Yuan Wei Chen

引用本文: Chang Yan Zhao,  Chang Qing Shi,  Yuan Wei Chen. Synthesis of urea acetates as potential PPARα/γ dual agonists[J]. Chinese Chemical Letters, 2008, 19(2): 166-168. doi: 10.1016/j.cclet.2007.12.013 shu
Citation:  Chang Yan Zhao,  Chang Qing Shi,  Yuan Wei Chen. Synthesis of urea acetates as potential PPARα/γ dual agonists[J]. Chinese Chemical Letters, 2008, 19(2): 166-168. doi: 10.1016/j.cclet.2007.12.013 shu

Synthesis of urea acetates as potential PPARα/γ dual agonists

  • 基金项目:

    The authors thank the 100 Talents program of Chinese Academy of Sciences, the Chengdu Institute of Organic Chemistry, and the Graduate School of the Chinese Academy of Sciences for financial support of this work.

摘要: In the quest for novel PPARα/γ dual agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we designed and synthesized a series of urea acetates as potential PPARα/γ dual agonists.The structure of the target compounds, intermediates were characterized by 1H NMR, HRMS.

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  • 收稿日期:  2007-09-28
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