引用本文:
Fang Yuan, Fu Chen, Qing Yu Xiang, Xuan Qin, Zhi Rong Zhang, Yuan Huang. Synthesis and characterization of HPMA copolymer-5-FU conjugates[J]. Chinese Chemical Letters,
2008, 19(2): 137-140.
doi:
10.1016/j.cclet.2007.10.035
Citation: Fang Yuan, Fu Chen, Qing Yu Xiang, Xuan Qin, Zhi Rong Zhang, Yuan Huang. Synthesis and characterization of HPMA copolymer-5-FU conjugates[J]. Chinese Chemical Letters, 2008, 19(2): 137-140. doi: 10.1016/j.cclet.2007.10.035
Citation: Fang Yuan, Fu Chen, Qing Yu Xiang, Xuan Qin, Zhi Rong Zhang, Yuan Huang. Synthesis and characterization of HPMA copolymer-5-FU conjugates[J]. Chinese Chemical Letters, 2008, 19(2): 137-140. doi: 10.1016/j.cclet.2007.10.035
Synthesis and characterization of HPMA copolymer-5-FU conjugates
摘要:
N-(2-Hydroxypropyl) methacrylamide copolymer-5-fluorouracil (PHPMA-FU) conjugates were synthesized by a novel and simplified synthetic mute, and characterized by UV, FTIR and HPLC analyses.The conjugated content of 5-fluorouracil (5-FU) was 3.41±0.07 wt%.The stabilities of PHPMA-FU conjugates under different conditions were studied.The results showed that HPMA copolymer was a potential carrier for tumor-targeting delivery of 5-FU.
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关键词:
- HPMA copolymer
- / 5-Fluorouracil
- / Conjugates
- / Characterization
- / Stability
English
Synthesis and characterization of HPMA copolymer-5-FU conjugates
Abstract:
N-(2-Hydroxypropyl) methacrylamide copolymer-5-fluorouracil (PHPMA-FU) conjugates were synthesized by a novel and simplified synthetic mute, and characterized by UV, FTIR and HPLC analyses.The conjugated content of 5-fluorouracil (5-FU) was 3.41±0.07 wt%.The stabilities of PHPMA-FU conjugates under different conditions were studied.The results showed that HPMA copolymer was a potential carrier for tumor-targeting delivery of 5-FU.
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Key words:
- HPMA copolymer
- / 5-Fluorouracil
- / Conjugates
- / Characterization
- / Stability
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