New Metabolites of Aconitine in Rabbit Urine

Hong Gui ZHANG Xiang Guo SHI Ying SUN Ming Yu DUAN Da Fang ZHONG

引用本文: Hong Gui ZHANG,  Xiang Guo SHI,  Ying SUN,  Ming Yu DUAN,  Da Fang ZHONG. New Metabolites of Aconitine in Rabbit Urine[J]. Chinese Chemical Letters, 2002, 13(8): 758-760. shu
Citation:  Hong Gui ZHANG,  Xiang Guo SHI,  Ying SUN,  Ming Yu DUAN,  Da Fang ZHONG. New Metabolites of Aconitine in Rabbit Urine[J]. Chinese Chemical Letters, 2002, 13(8): 758-760. shu

New Metabolites of Aconitine in Rabbit Urine

  • 基金项目:

    This research project (39870874) was supported by the National Natural Science Foundation of China.

摘要: A sensitive analytical method to identify and determine aconitine and its metabolites in rabbit urine was developed by liquid chromatography-electrospray ionization mass spectometry (LC/ESI-MSn).In this method,aconitine and its four metabolites in rabbit urine were isolated and deduced as 16-O-demethylaconine (M1),benzoylaconine(M2),16-O-demethylbenzoylaconine (M3)and aconie(M4).M1 and M3 are new metabolites of aconitine and M2 and M4 are first identified in urine.

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  • 收稿日期:  2002-01-28
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