Citation:
JI Jian, FENG Linxian, QIU Yongxin, YU Xiaojie, YANG Shilin. IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER*[J]. Chinese Journal of Polymer Science,
1997, 15(2): 180-186.
IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER*
摘要:
A new reactive graft copolymer, poly(tetramthylene glycol) - graft-w-propyl sodiumsulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH2CH2CH2SO3-Na+), was synthesizedby the cationic polymerization of a-w-bifunctional PEG macromonomer (O?CH2—PEG——CH2 CH2 CH2 SO3 Na) and THF. The obtained copolymer exhibits the expected structureas indicated by the result of characterization. Two amino acids (L-arginine, L-tyrosine)were covalently attached to the copolymer after converting the sulfonate group to sulfonyl chloride.So the new reactive graft copolymer(PTMG-g-PEG-CH2CH2SO3-Na+) is expected to be very useful in attachment of potentially bioactive moieties to polymer via a hydrophilic PEG spacer.
English
IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER*
Abstract:
A new reactive graft copolymer, poly(tetramthylene glycol) - graft-w-propyl sodiumsulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH2CH2CH2SO3-Na+), was synthesizedby the cationic polymerization of a-w-bifunctional PEG macromonomer (O?CH2—PEG——CH2 CH2 CH2 SO3 Na) and THF. The obtained copolymer exhibits the expected structureas indicated by the result of characterization. Two amino acids (L-arginine, L-tyrosine)were covalently attached to the copolymer after converting the sulfonate group to sulfonyl chloride.So the new reactive graft copolymer(PTMG-g-PEG-CH2CH2SO3-Na+) is expected to be very useful in attachment of potentially bioactive moieties to polymer via a hydrophilic PEG spacer.
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