Citation: Li Ping ZHANG, Yi Qun LI, Mei Yun ZHOU. Efficient and Eco-friendly Process for the Synthesis of Bi(indolyl)methanes Catalyzed by Sodium Hydrogensulfate Monohydrate in Ionic Liquid n-Butylpyridinium Tetrafluoroborate[J]. Chinese Chemical Letters, ;2006, 17(6): 723-726. shu

Efficient and Eco-friendly Process for the Synthesis of Bi(indolyl)methanes Catalyzed by Sodium Hydrogensulfate Monohydrate in Ionic Liquid n-Butylpyridinium Tetrafluoroborate

Department of Chemistry, Jinan University, Guangzhou 510632

Received Date: 31 October 2005

Fund Project: The project was supported by the National Natural Science Foundation of China (No. 20272018) and the Guangdong Natural Science Foundation (No. 04010458, 021166).

Efficient electrophilic substitution reaction of indoles with various aromatic aldehydes were carried out with a catalytic amount of sodium hydrogensulfate monohydrate (NaHSO₄·H₂O) in ionic liquid n-butylpyridinium tetrafluoroborate ([Bpy]BF₄) to afford the corresponding bi(indolyl)methanes in excellent yields. The notable advantages of this protocol in terms of low cost of catalyst and ionic liquid, mild conditions, simple operation, short reaction time, high yields and recycling of the ionic liquid.
- Bi(indolyl)methane,
- ionic liquid,
- sodium hydrogen sulfate
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