Citation: Ping XUE, Guan Zhong LU, Wan Yi LIU. Poly(GMA/MA/MBAA) Copolymer Beads: a Highly Efficient Support Immobilizing Penicillin G Acylase[J]. Chinese Chemical Letters, ;2006, 17(1): 129-132. shu

Poly(GMA/MA/MBAA) Copolymer Beads: a Highly Efficient Support Immobilizing Penicillin G Acylase

1.
Key Laboratory of Energy Source and Chemical Engineering, Ningxia University, Yinchuan 750021;
2.
Research Institute of Industrial Catalysis, East China University of Science and Technology, Shanghai 200237

Received Date: 28 April 2005

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 20564002) and the State Key Program of Fundamental Research (No. 2004CCA05900).

The hydrophilic, macroporous and beaded ternary copolymer of glycidyl methacrylate (GMA)/methacrylamide(MA)/N, N'-methylene-bis(acrylamide)(MBAA)was synthesized using the industrial agents by inverse suspension polymerization. The apparent activity of the immobilized penicillin G acylase reached 1096 IU/g for hydrolysis penicillin G on the beads with diameter of 0.11-0.13 mm, and it changed hardly after 50 cycles. It can be expected to be a good potential in industrial application.
- Poly(GMA/MA/MBAA) copolymer beads,
- penicillin G acylase,
- immobilization,
- inverse suspension polymerization
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