Citation: Xin ZHOU, Shrong Shi LIN, Jin Fang YUAN, Zhe Ming WANG, Hong Zhong WANG. Spectral and Mechanistic Studies of the Reactions of Substituted 1,5-Benzothiazepine with Dichloroacetyl Chloride and Triethylamine[J]. Chinese Chemical Letters, ;2001, 12(10): 851-854. shu

Spectral and Mechanistic Studies of the Reactions of Substituted 1,5-Benzothiazepine with Dichloroacetyl Chloride and Triethylamine

1.
College of Chemical and Molecular Engineering, Peking University, Beijing 100871;
2.
Department of Biological Sciences & Biotechnology, Tsinghua University, Beijing 100084

Received Date: 19 January 2001

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 29972001).

A [2+2] cycloaddition adduct 2 and a novel ring-opening product 3 were obtained from the reactions of 2,3-benzothiazepines 1 with dichloroacetyl chloride and triethylamine. The relative ratios of 2 and 3 were affected by the addition order of reactants and reaction temperature. The structures were determined by spectral data and the reaction mechanisms for the formation of 2 and 3 were elucidated.
- Benzothiazepine,
- dichloroacetyl chloride,
- cycloaddition adduct,
- ring-opening product
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