Citation: Yong DENG, Yu YANG, Hui JIN, Yu Guo ZHONG. Synthesis of Some Potential Antiangiogenic 1,3-Dihydro-1,3-dioxo 2H-isoindole Derivatives[J]. Chinese Chemical Letters, ;2004, 15(10): 1173-1176. shu

Synthesis of Some Potential Antiangiogenic 1,3-Dihydro-1,3-dioxo 2H-isoindole Derivatives

Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041

Received Date: 8 September 2003

Based on the structure-activity relationships of RGD-containing peptides, a series of 1,3-dihydro-1,3-dioxo-2H-isoindole derivatives were synthesized. All of them were first reported.Their structures were confirmed by spectral data and elemental analysis. Their ability to inhibit angiogenesis were evaluated in the chick embryo chorioallantoic membrane assay at 10^-5 mol/L.Compounds 5b and 5e displayed obviously antiangiogenic activity.
- RGD sequence,
- α_vβ₃ receptor,
- 1,3-dihydro-1,3-dioxo-2H-isoindole derivatives,
- synthesis,
- antiangiogenic activity
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