Citation: Pei Qiang HUANG, Xiang Su FEI, Hong ZHENG. α-AMIDOALKYLATION VIA SULFONES:TOWARDS THE SYNTHESIS OF ANT VENOM ALKALOIDS[J]. Chinese Chemical Letters, ;1995, 6(9): 739-742. shu

α-AMIDOALKYLATION VIA SULFONES:TOWARDS THE SYNTHESIS OF ANT VENOM ALKALOIDS

Department of Chemistry, Xiamen University, Xiamen 361005

Received Date: 24 January 1995

Fund Project: Financial support from FOK YING TUNG Education Foundation and the Natural Science Foundation of China is gratefully acknowledged.

We described the synthesis of two S-substituted γ-lactams 1 and 11 by sulfone-based α-amidoalkylation method.This constitutes the formal synthesis of ant venom alkaloids 2 and 3 in racemic form.The key intermediate 18 for the chiral synthesis of 2 and 3 was prepared from new chiral sulfone 7 by the same method.
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