Citation: Rong ZHENG, Chang Jin ZHU, Yi LIU, Dong WANG. Synthesis of a Pair of Derivatives of N-Methylpyrrole Polyamide[J]. Chinese Chemical Letters, ;2006, 17(4): 434-436. shu

Synthesis of a Pair of Derivatives of N-Methylpyrrole Polyamide

Department of Applied Chemistry, Beijing Institute of Technology, Beijing 100081

Received Date: 14 September 2005

Fund Project: We thank the National Natural Science Foundation of China (No.20372009, 20132020) and National 973 Program of China (No.2003CB514126) for their financial supports.

A pair of derivatives of tetrameric N-methylpyrrole polyamide were synthesized in order to develop a new method for the study of interaction of the polyamide derivatives with DNA. Indole acetic acid and nicotinic acid were introduced to the polyamide in the synthesized compound, which showed an expected red shift in the UV spectrum. These compounds may function as a potential tool in the detection of the polyamide binding to DNA.
- Synthesis,
- polyamide derivatives,
- ultraviolet absorption
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