Citation: De Xin WANG, Gui Shen LU. MULTIPLE SYNTHESIS OF SMALLPEPTIDE ANALOGS[J]. Chinese Chemical Letters, ;1993, 4(5): 399-402. shu

MULTIPLE SYNTHESIS OF SMALLPEPTIDE ANALOGS

De Xin WANG ,
Gui Shen LU

Institute of Materia, Chinese Academy of Medical Sciences, Beijing, 100050

Received Date: 6 February 1993

Two peptide analogs H-Tyr-Thr-Pro-Arg-Lys-OH (1) and H-Tyr-Thr-Pro-Phe-Lys-OH (2) were prepared successfully by the technique of simultaneous multiple peptides synthesis(SMPS) on a single resin support. The profiles of HPLC and amino acid analysis indicated that the purity of 1 and 2 was satisfactory. The average yield (74.9%) of each peptide was reasonable. This new technique of SMPS offered significant savings not only in time but in many expensive reagents as well.
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