Citation: Bin SU, Hui LI, Meng Shen CAI, Zhong Jun LI. On the Mechanism of Condensation between 5-Amino-4, 6-dichloro-2-methylpyrimidine and 1-Acetyl-2-imidazolin-2-one[J]. Chinese Chemical Letters, ;2002, 13(3): 207-210. shu

On the Mechanism of Condensation between 5-Amino-4, 6-dichloro-2-methylpyrimidine and 1-Acetyl-2-imidazolin-2-one

Department of Chemical Biology, School of Pharmaceutical science, Peking University, Beijing 100083

Received Date: 15 June 2001

The condensation reaction between 5-amino-4, 6-dichloro-2-methylpyrimidine and 1-acetyl-2-imidazolin-2-one using POCl₃ as solvent gave 4, 6-dichloro-2-methyl-5-(l-acetyl-tetrahydro-imidazo-2-ylidene)-aminopyrimidine predominantly and 4, 6-dichloro-2-methyl-5-{1-[ l-(2-oxo-tetrahydro-imidazolyl)]-acetyene}-aminopyrimidine as by-product. No 4, 6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine was found. The result indicated an esterifi-cation-addition-elimination mechanism.
- Moxonidine,
- X-ray single crystal diffiaction,
- GHMBC
1. [1]
  Fuai Hu , Yanru Yin , Yang Li , Feifei Guo , Jianhui Liu , Zeliang Gao . Super internal electrostatic field effect on self-powered X-ray detector in ferroelectric Pb(Mg1/3Nb2/3)O3-PbTiO3 single crystal. Chinese Journal of Structural Chemistry, 2026, 45(5): 100863-100863. doi: 10.1016/j.cjsc.2025.100863
2. [2]
  Jingqi Ma , Huangjie Lu , Junpu Yang , Liangwei Yang , Jian-Qiang Wang , Xianlong Du , Jian Lin . Rational design and synthesis of a uranyl-organic hybrid for X-ray scintillation. Chinese Journal of Structural Chemistry, 2024, 43(5): 100275-100275. doi: 10.1016/j.cjsc.2024.100275
3. [3]
  Xin Dong , Jing Liang , Zhijin Xu , Huajie Wu , Lei Wang , Shihai You , Junhua Luo , Lina Li . Exploring centimeter-sized crystals of bismuth-iodide perovskite toward highly sensitive X-ray detection. Chinese Chemical Letters, 2024, 35(6): 108708-. doi: 10.1016/j.cclet.2023.108708
4. [4]
  Xiuwen Xu , Quan Zhou , Yacong Wang , Yunjie He , Qiang Wang , Yuan Wang , Bing Chen . Expanding the toolbox of metal-free organic halide perovskite for X-ray detection. Chinese Chemical Letters, 2024, 35(9): 109272-. doi: 10.1016/j.cclet.2023.109272
5. [5]
  Jueqiong Wang , Liwei Cheng , Yang Yang , Dewen He , Yingtong Fan , Zhiwei Li , Junhao Lu , Yumin Wang , Jia Lei , Zhiyong Peng , Aiping Jin , Dan Zhou , Zhizai Li , Shuaihua Wang , Lixi Chen , Yaxing Wang , Yanlong Wang , Shuao Wang . Flexible two-dimensional uranium-organic framework with upgraded radiation resistant for X-ray imaging. Chinese Chemical Letters, 2026, 37(5): 111614-. doi: 10.1016/j.cclet.2025.111614
6. [6]
  Hong-Jin Liao , Zhu Zhuo , Qing Li , Yoshihito Shiota , Jonathan P. Hill , Katsuhiko Ariga , Zi-Xiu Lu , Lu-Yao Liu , Zi-Ang Nan , Wei Wang , You-Gui Huang . A new class of crystalline X-ray induced photochromic materials assembled from anion-directed folding of a flexible cation. Chinese Chemical Letters, 2024, 35(8): 109052-. doi: 10.1016/j.cclet.2023.109052
7. [7]
  Xuying Yu , Jiarong Mi , Yulan Han , Cai Sun , Mingsheng Wang , Guocong Guo . A stable radiochromic semiconductive viologen-based metal–organic framework for dual-mode direct X-ray detection. Chinese Chemical Letters, 2024, 35(9): 109233-. doi: 10.1016/j.cclet.2023.109233
8. [8]
  Xin Dong , Tianqi Chen , Jing Liang , Lei Wang , Huajie Wu , Zhijin Xu , Junhua Luo , Li-Na Li . Structure design of lead-free chiral-polar perovskites for sensitive self-powered X-ray detection. Chinese Journal of Structural Chemistry, 2024, 43(6): 100256-100256. doi: 10.1016/j.cjsc.2024.100256
9. [9]
  Yan-Jiang Li , Shu-Lei Chou , Yao Xiao . Detecting dynamic structural evolution based on in-situ high-energy X-ray diffraction technology for sodium layered oxide cathodes. Chinese Chemical Letters, 2025, 36(2): 110389-. doi: 10.1016/j.cclet.2024.110389
10. [10]
  Huawei Yang , Jianbo Wu , Zeng-Kui Zhu , Hang Li , Panpan Yu , Ying Zeng , Qingran Ding , Guirong Chen , Lijun Xu , Zhangtong Han , Haiqing Zhong , Yueying Wang , Wenhui Wu , Junhua Luo . Highly resistive lead-free perovskite ferroelectric enables self-driven X-ray detection with ultralow dose. Chinese Chemical Letters, 2026, 37(3): 110682-. doi: 10.1016/j.cclet.2024.110682
11. [11]
  Xue-Na Tang , Qingshun Fan , Guang-Ning Liu , Cuncheng Li , Zhihua Sun . Exceptional one-dimensional hybrid lead halide for high-performance X-ray detection through hydrogen bond enhanced charge transport. Chinese Chemical Letters, 2026, 37(6): 111036-. doi: 10.1016/j.cclet.2025.111036
12. [12]
  Yu Pang , Min Wang , Ning-Hua Yang , Min Xue , Yong Yang . One-pot synthesis of a giant twisted double-layer chiral macrocycle via [4 + 8] imine condensation and its X-ray structure. Chinese Chemical Letters, 2024, 35(10): 109575-. doi: 10.1016/j.cclet.2024.109575
13. [13]
  Pan Gao , Qingzheng Kong , Ying Sun , Qian Ma , Qi Wang , Zeyu Guo , Ledi Li , Bingbing Li , Jingwei Xu , Xiaomei Jiang , Zhaolai Chen . One-dimensional (C12H12N)3Cu3I6 for high-performance direct X-ray detection. Chinese Journal of Structural Chemistry, 2026, 45(1): 100767-100767. doi: 10.1016/j.cjsc.2025.100767
14. [14]
  Zhong Du , Li-Jun Zhu , Jia-Bao Xiong , Yu-Xiang Gao , Ya-Qi Cui , Maierhaba Aili , Chen-Yang Chu , Chi Zhang , Gao-Fei Huang , Xue-Liang Zhang , Nuernisha Alifu , Biao Dong . Multifunctional FA-PDA@ICG-Bi₂Se₃ nanoplatform for targeted NIR and X-ray dual-modal imaging and photothermal therapy of cervical cancer. Chinese Chemical Letters, 2026, 37(4): 111488-. doi: 10.1016/j.cclet.2025.111488
15. [15]
  Jiaxuan Liu , Nan Zhang , Huiming Shi , Zhipeng He , Zhiyu Zhang , Dianlong Wang , Huakun Liu , Shixue Dou , Bo Wang . Single crystal P2-type layered cathodes with optimized crystal plane orientation improved high voltage stability for sodium-ion batteries. Chinese Chemical Letters, 2026, 37(5): 110892-. doi: 10.1016/j.cclet.2025.110892
16. [16]
  Xiaoyu Zhao , Kai Gao , Sen Xue , Wei Ran , Rui Liu . Synergistic effects of oxygen vacancies and Pd single atoms on Pd@TiO_2−x for efficient HER catalysis. Chinese Chemical Letters, 2025, 36(6): 110309-. doi: 10.1016/j.cclet.2024.110309
17. [17]
  Fengyu Zhang , Yali Liang , Zhangran Ye , Lei Deng , Yunna Guo , Ping Qiu , Peng Jia , Qiaobao Zhang , Liqiang Zhang . Enhanced electrochemical performance of nanoscale single crystal NMC811 modification by coating LiNbO₃. Chinese Chemical Letters, 2024, 35(5): 108655-. doi: 10.1016/j.cclet.2023.108655
18. [18]
  Min Chen , Boyu Peng , Xuyun Guo , Ye Zhu , Hanying Li . Polyethylene interfacial dielectric layer for organic semiconductor single crystal based field-effect transistors. Chinese Chemical Letters, 2024, 35(4): 109051-. doi: 10.1016/j.cclet.2023.109051
19. [19]
  Zhenfei Tang , Yunwu Zhang , Zhiyuan Yang , Haifeng Yuan , Tong Wu , Yue Li , Guixiang Zhang , Xingzhi Wang , Bin Chang , Dehui Sun , Hong Liu , Lili Zhao , Weijia Zhou . Iron-doping regulated light absorption and active sites in LiTaO₃ single crystal for photocatalytic nitrogen reduction. Chinese Chemical Letters, 2025, 36(3): 110107-. doi: 10.1016/j.cclet.2024.110107
20. [20]
  Xin Chen , Zaiwang Zhao , Yujuan Zhao . Uniform single-crystal mesoporous metal-organic frameworks with tunable architectures. Chinese Journal of Structural Chemistry, 2025, 44(9): 100655-100655. doi: 10.1016/j.cjsc.2025.100655

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(1635)
HTML views(53)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return