Citation: Lan JIN, Pin YANG. The Interaction of Cobalt (Ⅲ) Mixed-Ligand Coordination Compound Containing Dipyrido[3,2-a:2',3'-c] phenazine With Calf Thymus DNA[J]. Chinese Chemical Letters, ;1997, 8(6): 551-552. shu

The Interaction of Cobalt (Ⅲ) Mixed-Ligand Coordination Compound Containing Dipyrido[3,2-a:2',3'-c] phenazine With Calf Thymus DNA

Lan JIN ^a,b ,
Pin YANG ^a,b

a State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093;
b Institute of Molecular Science, Shanxi University, Taiyuan 030006

Received Date: 9 September 1996

The binding of Co(phen)₂dppz³⁺ to calf thymus DNA was investigated using absorption spectroscopy,viscosity and electrophoresis measurements,where dppz is dipyrido[3,2-a:2'3'-c] phenazine.The compound shows absorption hypochromicity and the specific viscosity increased upon binding to calf thymus DNA.The complex is also shown to be more efficient photosensitisers for single strand breaks in plasmid DNA.
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