Citation: Shao Ning WANG, Ying Kun QIU, Hui XU, Yi Hui DENG, Da Wei CHEN. Synthesis and Characterization of a Novel Galactosylated Cholesterol[J]. Chinese Chemical Letters, ;2006, 17(2): 173-176. shu

Synthesis and Characterization of a Novel Galactosylated Cholesterol

1.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016;
2.
School of Pharmcy, Yantai University, Yantai 264005;
3.
Shandong Engineering Research Center of Natural Drugs, Yantai 264003

Received Date: 2 June 2005

A novel galactosylated cholesterol with mono-galactoside moiety, (5-cholesten-3-yl)4-oxo-4-[2-(lactobionylamido)ethylamido]butanoate 6 was synthesized. Its chemical structure was characterized by IR, ESI-MS, ¹³C NMR, ¹H NMR. Doxorubicin entrapped in the liposomes containing 10% mol/mol 6 was rapidly accumulated in liver and mainly uptake by parenchymal cells in mice.
1. [1]
  Chengying Wang , Bohan Chen , Yuming Wang , Bingyu Xie , Peishuang Yu , Xiaojie Xu , Rui Wang , Lin Miao , Xiaohui Yan , Yubo Li , Yunfei Li , Wei Huang . Advances of nanomedicine targeting the interface of cholesterol metabolism and immune evasion. Chinese Chemical Letters, 2025, 36(12): 110921-. doi: 10.1016/j.cclet.2025.110921
2. [2]
  Hongyi Huang , Siyao Che , Wenjie Zhou , Yunchu Zhang , Weiling Zhuo , Xijing Yang , Songping Zheng , Jiagang Liu , Xiang Gao . Apatinib potentiates doxorubicin with cRGD-functionalized pH-sensitive micelles against glioma. Chinese Chemical Letters, 2025, 36(5): 110084-. doi: 10.1016/j.cclet.2024.110084
3. [3]
  Ya-Jie Zhu , Zhi-Min Lv , Hao-Feng Zhu , Qi-Yan Qi , Shang-Bo Yu , Jia Tian , Wei Zhou , Zhan-Ting Li . Self-assembly of disassemblable supramolecular organic frameworks for doxorubicin delivery, photofrin posttreatment phototoxicity inhibition and heparin neutralization. Chinese Chemical Letters, 2026, 37(1): 111353-. doi: 10.1016/j.cclet.2025.111353
4. [4]
  Xin Liu , Haoran Zhu , Yi Wang , Haili Zhang , Yujie Li , Hongcheng Gao , Yi Han , Dejin Wang , Yunsheng Xia . Carbon dots-embedded hydrogel ratiometric fluorescent platform for portable determination of doxorubicin in clinical samples. Chinese Chemical Letters, 2026, 37(2): 111891-. doi: 10.1016/j.cclet.2025.111891
5. [5]
  Jia Wang , Yunxiu Fan , Shilin Xu , Zhouxue Wu , Tian Hu , Yun Lu , Yue Li , Kang Xiong , Hongjun Deng , Jingrong Huang , Bo Yang , Shaozhi Fu . Self-propelled biomotors co-deliver doxorubicin liposomes and aPD-1 antibody to fight breast cancer. Chinese Chemical Letters, 2026, 37(2): 111607-. doi: 10.1016/j.cclet.2025.111607
6. [6]
  Xiaopeng Han , Jiayin Li , Fei Li , Zhongyue Yuan , Hao Li , Lei Yang , Yan-Ming Xia , Chao Teng , Chao Qin , Lifang Yin . ROS-sensitive dihydroartemisinin prodrug amplify chemo-immunotherapy efficacy of doxorubicin by coordinating robust tumor cell immunogenic cell death and PD-L1 blockade. Chinese Chemical Letters, 2026, 37(2): 111335-. doi: 10.1016/j.cclet.2025.111335
7. [7]
  Xiuzheng Deng , Changhai Liu , Xiaotong Yan , Jingshan Fan , Qian Liang , Zhongyu Li . Carbon dots anchored NiAl-LDH@In₂O₃ hierarchical nanotubes for promoting selective CO₂ photoreduction into CH₄. Chinese Chemical Letters, 2024, 35(6): 108942-. doi: 10.1016/j.cclet.2023.108942
8. [8]
  Yongliang Ban , Meng Zhang , Jianya He , Chunfeng Shao , Zhongliao Wang , Wei Zhao , Kai Dai . Atomically dispersed Fe–N₄ sites on g–C₃N₄ enable highly selective CO₂–to–CO electrocatalysis. Chinese Chemical Letters, 2026, 37(4): 112096-. doi: 10.1016/j.cclet.2025.112096
9. [9]
  Yu BAI , Jijiang WANG , Long TANG , Erlin YUE , Chao BAI , Xiao WANG , Yuqi ZHANG . A cadmium(Ⅱ) coordination polymer based on a semirigid tetracarboxylate ligand for highly selective detection of Fe³⁺ and 4-nitrophenol. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1217-1226. doi: 10.11862/CJIC.20240457
10. [10]
  Jiao Chen , Zihan Zhang , Guojin Sun , Yudi Cheng , Aihua Wu , Zefan Wang , Wenwen Jiang , Fulin Chen , Xiuying Xie , Jianli Li . Benzo[4,5]imidazo[1,2-a]pyrimidine-based structure-inherent targeting fluorescent sensor for imaging lysosomal viscosity and diagnosis of lysosomal storage disorders. Chinese Chemical Letters, 2024, 35(11): 110050-. doi: 10.1016/j.cclet.2024.110050
11. [11]
  Cheng-Cheng Jiao , Guang-Xing Dong , Ke Su , You-Xiang Feng , Min Zhang , Tong-Bu Lu . The construction of InVO₄/BiVO₄ heterojunction via cation-exchange for efficient and highly selective CO₂ photoreduction to methanol. Chinese Chemical Letters, 2026, 37(1): 110752-. doi: 10.1016/j.cclet.2024.110752
12. [12]
  Zhen Li , Peilu Song , Yujie Liu , Xiuyun Sun , Xin Zhai , Yu Rao . Developing potent anti-inflammatory IRAK4-targeting PROTACs with simplified CRBN ligands. Chinese Chemical Letters, 2026, 37(3): 111033-. doi: 10.1016/j.cclet.2025.111033
13. [13]
  Chenxi Shang , Boxuan Lu , Chongbei Wu , Shuqing Zhou , Luyan Shi , Tayirjan Taylor Isimjan , Xiulin Yang . Inducing electronic rearrangement through Co₃B-Mo₂B₅ catalysts: Efficient dual-function catalysis for NaBH₄ hydrolysis and 4-nitrophenol reduction. Chinese Chemical Letters, 2025, 36(9): 111152-. doi: 10.1016/j.cclet.2025.111152
14. [14]
  Débora Ferreira dos Santos Morais , José Luis Tirado , Carlos Pérez-Vicente , Fabiana Villela da Motta , Pedro Lavela , Mauricio Bomio , Sergio Lavela . Unlocking the performance of sodium-ion batteries by coating Na₃V₂(PO₄)₃ with Nb₂O₅. Acta Physico-Chimica Sinica, 2026, 42(2): 100180-0. doi: 10.1016/j.actphy.2025.100180
15. [15]
  Gaofeng WANG , Shuwen SUN , Lixin Meng , Dequn PENG . Syntheses and fluorescent sensing properties of two coordination polymers based on 9, 9′-dihexyl-2, 7-di(pyridin-4-yl)fluorene. Chinese Journal of Inorganic Chemistry, 2026, 42(2): 331-339. doi: 10.11862/CJIC.20250260
16. [16]
  Gang Hu , Chun Wang , Qinqin Wang , Mingyuan Zhu , Lihua Kang . The controlled oxidation states of the H₄PMo₁₁VO₄₀ catalyst induced by plasma for the selective oxidation of methacrolein. Chinese Chemical Letters, 2025, 36(2): 110298-. doi: 10.1016/j.cclet.2024.110298
17. [17]
  Xiaoqiang Wang , Fangyuan Zhou , Yue Liu , Zhongbiao Wu . CePO₄ supported Cr catalyst with superior sulfur tolerance for selective catalytic oxidation of ammonia. Chinese Chemical Letters, 2025, 36(7): 110420-. doi: 10.1016/j.cclet.2024.110420
18. [18]
  Dong-Xue Jiao , Hui-Li Zhang , Chao He , Si-Yu Chen , Ke Wang , Xiao-Han Zhang , Li Wei , Qi Wei . Layered (C5H6ON)2[Sb2O(C2O4)3] with a large birefringence derived from the uniform arrangement of π-conjugated units. Chinese Journal of Structural Chemistry, 2024, 43(6): 100304-100304. doi: 10.1016/j.cjsc.2024.100304
19. [19]
  Xianchen Hu , Junli Yang , Fang Gao , Zhiyong Zhao , Simin Liu . Highly selective [4+4] cross-photodimerization of (4a-azonia)anthracenes driven by confinement of D-A hetero-guest pair in cucurbit[10]uril host. Chinese Chemical Letters, 2025, 36(3): 109967-. doi: 10.1016/j.cclet.2024.109967
20. [20]
  Ze Luo , Yukun Zhu , Yadan Luo , Guangmin Ren , Yonghong Wang , Hua Tang . Photocatalytic selective oxidation of 5-hydroxymethylfurfural coupled with H₂ evolution over In₂O₃/ZnIn₂S₄ S-scheme heterojunction. Acta Physico-Chimica Sinica, 2026, 42(3): 100166-0. doi: 10.1016/j.actphy.2025.100166

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(1600)
HTML views(61)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return