Citation: Zhao Ming XIONG, Jiong YANG, Yu Lin LI, Ren An LIAO, Zheng Ming LI. ASYMMETRIC MICHAEL-TYPE ALKYLATION OF CHIRAL IMINES DIASTEREOSELECTIVE SYNTHESIS OF (+)-α-CYPERONE AND (-)-10-EPI-α-CYPERONE[J]. Chinese Chemical Letters, ;1996, 7(8): 695-696. shu

ASYMMETRIC MICHAEL-TYPE ALKYLATION OF CHIRAL IMINES DIASTEREOSELECTIVE SYNTHESIS OF (+)-α-CYPERONE AND (-)-10-EPI-α-CYPERONE

a State Key Laboratory of Applied Organic Chemistry and Instute of Organic Chemistry, Lanzhou University, Lanzhou 730000;
b State Key Laboratory of Elemento-Organic Chendsny, Nankai University, Tianjin 300071

Received Date: 6 June 1996

Fund Project: This project was supported by the National Natural Science Foundation of China.

A novel diastereoselective route to (+)-α-cyperone (1) and (-)-10-epi-α-cyperone (2) has been developed. The key step involves an asymmetric Michael addition of the corresponding chiral imine, derived from R-(+)-dihydrocarvone (3), to ethyl vinyl ketone.
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