Citation: . OBSERVATION OF DNA PARTIAL DENATURATION BY ATOMIC FORCE MICROSCOPY*[J]. Chinese Journal of Polymer Science, ;2004, 22(2): 117-122. shu

OBSERVATION OF DNA PARTIAL DENATURATION BY ATOMIC FORCE MICROSCOPY*

Received Date: 22 July 2003
Revised Date: 22 August 2003

Atomic force microscopy was used to investigate the DNA-cetyltrimethylammonium bromide (CTAB) complexes adsorbed on highly ordered pyrolytic graphite (HOPG). These complexes, at low concentrations, can automatically spread out on the surface of HOPG. The DNA-CTAB complexes display a typically extended structure rather than a globular structure. Partially denaturated DNA produced by binding CTAB to DNA is directly observed by AFM with high resolution.The three-dimensional resolution of partially denaturated DNA obtained by AFM is not available by any other technique at present.
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