Citation: Guo Jun ZHENG, Jian Jun WANG, Tian Rui REN, Liu YANG, Wan Ru SUN. Lipase-catalyzed hydrolysis of methyl-3-phenylglycidate[J]. Chinese Chemical Letters, ;2001, 12(4): 305-306. shu

Lipase-catalyzed hydrolysis of methyl-3-phenylglycidate

Guo Jun ZHENG ^1,2 ,
Jian Jun WANG ^1,2 ,
Tian Rui REN ² ,
Liu YANG ^1,2 ,
Wan Ru SUN ^1,2

1.
State Key Laboratory of Microbial Resources, Institute of Microbiology, CAS, Beijing, 100080;
2.
Laboratory of Chemistry Computer, Institute of Chemical Metallurgy, CAS, Beijing, 100080

Received Date: 5 September 2000

Fund Project: This work was supported by the National Natural Sciences Foundation of China

The enzymatic resolution of racemic methyl 3-phenylglycidate was investigated. It was found that the hydrolysis rate of (2S, 3R)-enantiomer was faster than that of (2R, 3S)-enantiomer by a new lipase. At optimal condition 96% of (2R, 3S)-methyl phenylglycidate with ee of 100% was recovered from the racemic mixture.
- Lipase,
- methyl 3-phenylglycidate,
- resolution,
- chirality.
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