Citation: Guo TANG, Gui Ji ZHOU, Feng NI, Li Ming HU, Yu Fen ZHAO. ³¹p NMR and ESI-MS Studies on Some Intermediates of the Peptide Coupling Reagents Triphenyl-chlorophosphoranes[J]. Chinese Chemical Letters, ;2005, 16(3): 385-388. shu

³¹p NMR and ESI-MS Studies on Some Intermediates of the Peptide Coupling Reagents Triphenyl-chlorophosphoranes

Guo TANG ^1, ,
Gui Ji ZHOU ¹ ,
Feng NI ¹ ,
Li Ming HU ¹ ,
Yu Fen ZHAO ^1,2

1.
The Key Laboratory for Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen 361005;
2.
The Key laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084

Received Date: 23 February 2004

Fund Project: The authors would like to thank the financial supports from the Fujian Foundation of Science and Technology(2001F008) and Fujian key Foundation of Science and Technology(2002H011)

The intermediates of the Appel coupling reagents were studied in acetonitrile,dimethoxyethane and dioxane by ³¹P NMR,¹³C NMR spectrum and ESI-MS. In dioxane a new high coordinated phosphorous compound with ³¹p NMR shift at -39 ppm was observed. The ESI-MS showed that it could be a penta-coordinated phosphorous compound containing dioxane. The carboxyl activated intermediates were also studied in three solvents.
- Triphenylphosphine,
- hexachloroethane,
- ³¹PNMR,
- ESI-MS,
- penta-coordinated phosphorous compound.
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