Citation: Xue Qin REN, Xiao Dan SU, Al Jin HUANG, Yi Liang SUN, Zeng Pei SUNZ. Separation of chiral drugs with β-CD phosphate by capillary electrophoresis[J]. Chinese Chemical Letters, ;2000, 12(2): 153-156. shu

Separation of chiral drugs with β-CD phosphate by capillary electrophoresis

1.
Department of Chemistry Peking University Beijing 100871;
2.
National Institute for the Control of pharmaceutical and Biological Products Beijing 100050

Received Date: 13 September 1999

β-Cyclodextrin phosphate (β-CD-phosphate) was used as a selector for separating chiral drugs by capillary electrophoresis (CE).A solution comprising of 120 mmol/L Britton-Robinson buffer (BRB) containing 10 mmol/L β-CD phosphate with the pH adjusted to 7.0 was used as the background electrolyte (BGE), and a small amount of analyte was injected (600v/1s).Triethylamine, diethylamine, triethanolamine, diethanolamine, Tris added as modifier were compared.Isoprenaline, methoxamine, oxprenolol, practolol were successfully resolved.
- Capillary electrophoresis, chiral separation, β-cyclodextrin-phosphate, isoprenaline, methoxamine, oxprenolol, practolol.
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