Citation: Li Xin WANG, Ming Hua XU, Yao Zeng SHI, Hong Wen HU. ULTRASONICALLY DISPERSED POTASSIUM AS DEPROTONATING AND COUPLING AGENT——SYNTHESIS OF 1,6-DINITRILES IN SITU[J]. Chinese Chemical Letters, ;1996, 7(8): 709-712. shu

ULTRASONICALLY DISPERSED POTASSIUM AS DEPROTONATING AND COUPLING AGENT——SYNTHESIS OF 1,6-DINITRILES IN SITU

Department of Chemistry, Nanjing University, Nanjing 210093

Received Date: 15 March 1996

Fund Project: This project was financed by the National Natural Science Foundation of China and the Ph.D Student Training Fund of the State Educational Comission of China.

Ultrasonically dispersed potassium (UDP) in toluene was found to be an effective deprotonating and coupling agent in the condensation of phenylacetonitrile with aldehydes;α, β-Unsaturated nitriles and their dimers 1, 6-dinitriles may be obtained by one-pot synthesis within few minutes.
1. [1]
  Zhaodong WANG . In situ synthesis, crystal structure, and magnetic characterization of a trinuclear copper complex based on a multi-substituted imidazo[1,5-a]pyrazine scaffold. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 597-604. doi: 10.11862/CJIC.20240268
2. [2]
  Bofei JIA , Zhihao LIU , Zongyuan GAO , Shuai ZHOU , Mengxiang WU , Qian ZHANG , Xiamei ZHANG , Shuzhong CHEN , Xiaohan YANG , Yahong LI . Cu(Ⅱ) and Cu(Ⅰ) complexes based on derivatives of imidazo[1,5-a]pyridine: Synthesis, structures, in situ metal-ligand reactions, and catalytic activity. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 1020-1036. doi: 10.11862/CJIC.20240317
3. [3]
  Zhiyuan Liu , Hui Peng , Xin Wang , Zhenghao Tang , Wenbo Hou , Bo Tao , Yue Li , Guofu Ma , Ziqiang Lei . Coupling of graphitic microcrystalline and available functional groups in hard carbon unlocking deep and fast potassium-ion storage. Chinese Chemical Letters, 2026, 37(2): 110592-. doi: 10.1016/j.cclet.2024.110592
4. [4]
  Yanyan Ma , Lizhen Xu , Muxin Xu , Jie Niu , Wei Xu , Weiying Lin . All in one: An in-situ activated tumor theranostic agent for NIR-Ⅱ fluorescence imaging guided surgical resection and photothermal therapy. Chinese Chemical Letters, 2025, 36(11): 110850-. doi: 10.1016/j.cclet.2025.110850
5. [5]
  Fengqing Wang , Changxing Qi , Chunmei Chen , Qin Li , Qingyi Tong , Weiguang Sun , Zhengxi Hu , Minyan Wang , Hucheng Zhu , Lianghu Gu , Yonghui Zhang . Discovery and enantioselective total synthesis of antitumor agent asperfilasin A via a regio- and diastereoselective Nazarov cyclization. Chinese Chemical Letters, 2025, 36(6): 110252-. doi: 10.1016/j.cclet.2024.110252
6. [6]
  Xinyu Hou , Xuelian Yu , Meng Liu , Hengxing Peng , Lijuan Wu , Libing Liao , Guocheng Lv . Ultrafast synthesis of Mo₂N with highly dispersed Ru for efficient alkaline hydrogen evolution. Chinese Chemical Letters, 2025, 36(4): 109845-. doi: 10.1016/j.cclet.2024.109845
7. [7]
  Shengkai Li , Yuqin Zou , Chen Chen , Shuangyin Wang , Zhao-Qing Liu . Defect engineered electrocatalysts for C–N coupling reactions toward urea synthesis. Chinese Chemical Letters, 2024, 35(8): 109147-. doi: 10.1016/j.cclet.2023.109147
8. [8]
  Bowen Wang , Longwu Sun , Qianqian Cao , Xinzhi Li , Jianai Chen , Shizhao Wang , Miaolin Ke , Fener Chen . Cu-catalyzed three-component CSP coupling for the synthesis of trisubstituted allenyl phosphorothioates. Chinese Chemical Letters, 2024, 35(12): 109617-. doi: 10.1016/j.cclet.2024.109617
9. [9]
  Jiyang Liu , Xiangzhang Tao , Zhenlei Zou , Jia Xu , Hui Shu , Yi Pan , Weigang Zhang , Shengyang Ni , Yi Wang . Modular and practical synthesis of gem-difluoroalkenes via consecutive Ni-catalyzed reductive cross-coupling. Chinese Chemical Letters, 2025, 36(7): 110461-. doi: 10.1016/j.cclet.2024.110461
10. [10]
  Yan-Li Li , Zhi-Ming Li , Kai-Kai Wang , Xiao-Long He . Beyond 1,4-addition of in-situ generated (aza-)quinone methides and indole imine methides. Chinese Chemical Letters, 2024, 35(7): 109322-. doi: 10.1016/j.cclet.2023.109322
11. [11]
  Wujun Jian , Mong-Feng Chiou , Yajun Li , Hongli Bao , Song Yang . Cu-catalyzed regioselective diborylation of 1,3-enynes for the efficient synthesis of 1,4-diborylated allenes. Chinese Chemical Letters, 2024, 35(5): 108980-. doi: 10.1016/j.cclet.2023.108980
12. [12]
  Yuexiang Liu , Xiangqiao Yang , Tong Lin , Guantian Yang , Xiaoyong Xu , Bubing Zeng , Zhong Li , Weiping Zhu , Xuhong Qian . Efficient continuous synthesis of 2-[3-(trifluoromethyl)phenyl]malonic acid, a key intermediate of Triflumezopyrim, coupling with esterification-condensation-hydrolysis. Chinese Chemical Letters, 2025, 36(1): 109747-. doi: 10.1016/j.cclet.2024.109747
13. [13]
  Yongli Zhao , Dingsheng Cao , Jie-Ping Wan , Yunyun Liu . Synthesis of 3-phosphinyl chromones via in situ iodination mediated C-H phosphination and the tunable synthesis of 2-phosphoryl chromanones. Chinese Chemical Letters, 2026, 37(1): 111740-. doi: 10.1016/j.cclet.2025.111740
14. [14]
  Mianling Yang , Meehyein Kim , Peng Zhan . Modular miniaturized synthesis and in situ biological evaluation facilitate rapid discovery of potent MraY inhibitors as antibacterial agents. Chinese Chemical Letters, 2025, 36(2): 110455-. doi: 10.1016/j.cclet.2024.110455
15. [15]
  Kun Chen , Huimin Lin , Xin Peng , Ziying Wu , Jingyue Dai , Yi Sun , Yaxuan Feng , Ziyi Huang , Zhiqiang Yu , Meng Yu , Guangyu Yao , Jigang Wang . In situ synthesis of MnO₂ micro/nano-adjuvants for enhanced immunotherapy of breast tumors. Chinese Chemical Letters, 2025, 36(5): 110045-. doi: 10.1016/j.cclet.2024.110045
16. [16]
  Xiaojin Wang , Yi Chang , Yuanyuan Zhang , Zhuohua Li , Haiqi Huang , Yansha Huang , Jiawei Hu , Kai Zhang , Xuemei Gong , Ruirui Zhao . In-situ construction and tuning of a poly(1,3-dioxolane) dual-interlayer electrolyte bolstering high performance of solid-state battery. Chinese Chemical Letters, 2026, 37(3): 110626-. doi: 10.1016/j.cclet.2024.110626
17. [17]
  Zhiwei Chen , Heyun Sheng , Xue Li , Menghan Chen , Xin Li , Qiuling Song . Efficient capture of difluorocarbene by pyridinium 1,4-zwitterionic thiolates: A concise synthesis of difluoromethylene-containing 1,4-thiazine derivatives. Chinese Chemical Letters, 2024, 35(4): 108937-. doi: 10.1016/j.cclet.2023.108937
18. [18]
  Qi Li , Zi-Lu Wang , Yun-He Xu . Copper-catalyzed 1,4-silylcyanation of 1,3-enynes: A silyl radical-initiated approach for synthesis of difunctionalized allenes. Chinese Chemical Letters, 2025, 36(3): 109991-. doi: 10.1016/j.cclet.2024.109991
19. [19]
  Lu Dai , Yuxin Ren , Shuang Li , Meidi Wang , Chentao Hu , Ya-Pan Wu , Guangtong Hai , Dong-Sheng Li . Room-temperature synthesis of Co(OH)₂/Mo₂TiC₂T_x hetero-nanosheets with interfacial coupling for enhanced oxygen evolution reaction. Chinese Chemical Letters, 2025, 36(4): 109774-. doi: 10.1016/j.cclet.2024.109774
20. [20]
  Chao LIU , Jiang WU , Zhaolei JIN . Synthesis, crystal structures, and antibacterial activities of two zinc(Ⅱ) complexes bearing 5-phenyl-1H-pyrazole group. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1986-1994. doi: 10.11862/CJIC.20240153

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(1363)
HTML views(42)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return