Citation: Ye WANG, Zhan Zhu LIU, Shi Zhi CHEN. Synthesis of a Dopamimetic Thionated Dipeptide Prodrug of L-DOPA[J]. Chinese Chemical Letters, ;2005, 16(6): 714-715. shu

Synthesis of a Dopamimetic Thionated Dipeptide Prodrug of L-DOPA

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 24 September 2004

Fund Project: The author thanks the National Natural Science Foundation of China (Project No.:30371681) and Beijing Municipal Natural Science Foundation (Project No.:7042041) for the financial support.

L-DOPA has gained widespread credit over the past decades as being the mainstay of the pharmacological treatment of Parkinson's disease. However, there are many adverse effects associated with the use of L-DOPA. The prodrug approach is the most promising way to solve the problem. In this article, a thionated dipeptide prodrug of L-DOPA 11 was synthesized via 10 steps in a total yield of 26.5% from L-DOPA.
- Prodrug,
- dipeptide,
- Parkinson's disease,
- L-DOPA
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