Citation: Zhen Yuan MIAO, Wan Nian ZHANG, Jian Zhong YAO, Chun Quan SHENG, Yun Long SONG, Hui XU, Min ZHANG, Jing ZHANG. Synthesis and Antitumor Activity of 7-Substituted Derivatives of Homocamptothecin[J]. Chinese Chemical Letters, ;2006, 17(6): 720-722. shu

Synthesis and Antitumor Activity of 7-Substituted Derivatives of Homocamptothecin

School of Pharmacy, Second Military Medical University, Shanghai 200433

Received Date: 1 December 2005

Fund Project: This research was supported by the National Natural Science Foundation of China (No.30371689).

Thirteen homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by the standard MTT method. The results showed that some of the homocamptothecin derivatives had higher antitumor activity than topotecan.
- Antitumor activity,
- homocamptothecin,
- synthesis
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