Citation: Yi LUO, Ren Xi ZHUO, Chang Lie FAN. SUSTAINED RELEASE OF LEVONORGESTREL USING POLYPHOSPHATE AS DRUG CARRIER[J]. Chinese Chemical Letters, ;1995, 6(4): 333-334. shu

SUSTAINED RELEASE OF LEVONORGESTREL USING POLYPHOSPHATE AS DRUG CARRIER

a Department of Chemistry, Peking University, Beijing 100871;
Department of Chemistry, Wuhan University, Wuhan 430072

Received Date: 7 November 1994

ABSTRACT A novel crosslinking polyphosphate was synthesized.The polymer was characterized by FT-IR,¹HNMR,³¹PNMR and elemental analysis.In vitro release of Levonorgestrel by single-matrix and sandwich pellet with polyphosphate as drug carrier were carried out in pH 7.4 phosphate buffer solution at 37℃.Sustained release rate from the sandwich pellet was more controlled than that from single-matrix pellet.
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