Citation: Chao Jie WANG, Jian Hong WANG, Ying GAN, Zhi Yong CHEN, Gang Jun DU, Jin ZHAO. Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine[J]. Chinese Chemical Letters, ;2006, 17(10): 1301-1304. shu

Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine

1.
College of Chemistry and Chemical Technology, Henan University, Kaifeng 475001;
2.
Key Lab of Special Function Material, Henan University, Kaifeng 475001;
3.
Medical College of Henan Unversity, Kaifeng 475001

Received Date: 29 April 2006

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 20472016), as well as by Henan Natural Science Foundation (No. 0423031800 No. 512001300).

A series of novel antitumor agents-the solanesylpiperazinotriamine derivatives were designed and synthesized, their structures were confirmed by IR, ¹H-NMR, MS, and element analysis. The preliminary tests showed that at low micromolar concentrations these compounds exhibited obvious toxicity on tumor cells in vitro, and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations they also evidently enhanced the curative effect of vincristine.
- Solanesylpiperazinotriamine,
- antitumor activity,
- synergistic effect
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