Citation: Xiao Yan ZHANG, Xin GAO, Yan LI, Xiao Dong FAN. Metallothionein Induction by Cd(Ⅱ) and Zn(Ⅱ)[J]. Chinese Chemical Letters, ;2006, 17(2): 269-272. shu

Metallothionein Induction by Cd(Ⅱ) and Zn(Ⅱ)

Xiao Yan ZHANG ^1,2,3, ,
Xin GAO ² ,
Yan LI ² ,
Xiao Dong FAN ¹

1.
Northwestern Polytechnical University, Xi'an 710072;
2.
School of Chemical Engineering, Northwest University, Xi'an 710069;
3.
The Hospital Lab, New York University

Received Date: 13 June 2005

The induction of MT(metallothionein) by Cd(Ⅱ) and Zn(Ⅱ) in renal proximal tubule cells (LLC-PKI) and the effects of simultaneous administration of Cd(Ⅱ) and Zn(Ⅱ) on MT induction were discussed. The two metals administered together are able to induce MT to almost 40μg MT/mg protein. The additive production of MT may be due to two different effects by Cd(Ⅱ) and Zn(Ⅱ) on the activation of MT transcription. The experiments of simultaneous administration of Cd(Ⅱ) and Zn(Ⅱ) to the renal proximal tubule cells demonstrated the interaction of these metals, MT induction and proximal tubule toxicity.
- Metal,
- metallothionein,
- induction,
- toxicity
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