Citation: Chang Xue LIN, Hua FU, Guang Zhong TU, Yu Fen ZHAO. Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates[J]. Chinese Chemical Letters, ;2003, 14(8): 779-782. shu

Synthesis and Chiral Separation of Dinucleotide (TpAZT) Phosphoramidates

1.
Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084;
2.
Beijing Institute of Microchemistry, Beijing 100091

Received Date: 8 October 2002

Fund Project: The authors would like to thank the financial supports from the National Natural Science Foundation of China (No.29902003, 20132020 and 20175026), the Ministry of Science and Technology, the Chinese Ministry of Education and Tsinghua University.

Dinucleotide (TpAZT) phosphoramidates were synthesized by Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (R_p and S_p) were separated by crystallization, and the results showed that natural and cheap methyl esters of alanine and phenylalanine can be used for large-scale synthesis of dinucleotide analogs.
- Dinucleotide phosphoramidate,
- chiral auxiliary,
- chiral separation
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