Citation: JI Jian, FENG Linxian, QIU Yongxin, YU Xiaojie, YANG Shilin. IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER*[J]. Chinese Journal of Polymer Science, ;1997, 15(2): 180-186. shu

IMMOBILIZATION OF POTENTIALLY BIOACTIVE MOIETIES ONTO POLYETHER WITH POLY(ETHYLENE GLYCOL)-SULFONATE SPACER*

JI Jian ^{**，封麟先，邱永兴，俞小洁，杨士林} ,
FENG Linxian ,
QIU Yongxin ,
YU Xiaojie ,
YANG Shilin

Received Date: 12 April 1996

A new reactive graft copolymer, poly(tetramthylene glycol) - graft-w-propyl sodiumsulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH2CH2CH2SO3-Na+), was synthesizedby the cationic polymerization of a-w-bifunctional PEG macromonomer (O?CH2—PEG——CH2 CH2 CH2 SO3 Na) and THF. The obtained copolymer exhibits the expected structureas indicated by the result of characterization. Two amino acids (L-arginine, L-tyrosine)were covalently attached to the copolymer after converting the sulfonate group to sulfonyl chloride.So the new reactive graft copolymer(PTMG-g-PEG-CH2CH2SO3-Na+) is expected to be very useful in attachment of potentially bioactive moieties to polymer via a hydrophilic PEG spacer.
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